截止目前，引用Bioss產品發表的文獻共35263篇，總影響因子175,814.81分，發表在Nature, Science, Cell以及Immunity等頂級期刊的文獻共126篇，合作單位覆蓋了清華、北大、復旦、華盛頓大學、麻省理工學院、東京大學以及紐約大學等上百所國際研究機構。
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本文主要分享引用Bioss產品發表文章至Signal Transduction and Targeted Therapy, Journal of Thoracic Oncology, Bioactive Materials, Advanced Functional Materials等期刊的10篇IF≥19的文獻摘要，讓我們一起欣賞吧。

文獻引用產品：

bsm-60738R | Ki67 Recombinant Rabbit mAb | IHC

bs-0646R | CD34 Rabbit pAb | IHC

作者單位：南方醫科大學

摘要：Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) capable of penetrating deeply into tumor tissues utilizing the photodynamic-triggered explosive energy and receptor-mediated transcytosis, significantly enhancing the therapeutic efficacy of breast cancer. The photodynamic gel-bombs were fabricated by loading powerful components of chlorin e6 and MnO₂ nanoparticles, as well as Doxorubicin, into a crosslinked Ca²⁺-gel. Upon exposure to laser irradiation, the obtained photodynamic gel-bombs are capable of generating explosive energy, resulting in their fragmentation into numerous nanofragments. The photodynamic-triggered explosive energy subsequently drives these nanofragments to deeply penetrate into tumor tissues through gap leakage among tumor cells. In addition, the photodynamic-triggered explosive energy also promotes the escape of those therapeutic components (including chlorin e6, MnO₂ nanoparticles, and doxorubicin) and nanofragments from lysosomes. In the subsequent stages, these nanofragments also exhibit excellent transcytosis capacity, facilitating deep penetration into tumor tissues. As expected, the enhanced penetration and accumulation of therapeutic components into tumor tissues can be achieved, significantly enhancing the anti-proliferation capacity against breast cancer.

Journal of Thoracic 

Oncology [IF=20.8]

作者單位：同濟大學醫學院

Bioactive Materials [IF=20.3]

文獻引用產品：

Advanced Functional 

Materials [IF=19]

文獻引用產品：

Advanced Functional 

Materials [IF=19]

文獻引用產品：

Advanced Functional 

Materials [IF=19]

文獻引用產品：

bs-2696R | S100-A8 / MRP8 Rabbit pAb | IF

作者單位：四川大學

摘要：Inhalation offers a non-invasive method to administer drugs to lungs, but achieving selective delivery to pulmonary lesions while sparing normal lung tissues remains challenging. Here, the development of an inhalable chemotactic liposome designed for targeted modulation of pulmonary pre-metastatic niche (PMN) is reported. The inhaled liposome can migrate along chemokine gradients, preferentially accumulating in chemokine-secreting PMNs within the lung. Upon localized drug release, the liposome mitigates fibrosis, and disrupts PMN evolution, thereby attenuating the pro-metastatic role of PMN as a hospitable “soil" for residual tumor cell “seeding" post-surgery. This approach further complements a sprayable hydrogel developed for immediate post-surgical application within the tumor resection cavity. While this hydrogel alone reduces the metastatic potential of postoperative tumor residues, it proves insufficient in halting the spread to lungs. However, the integration of the inhalable liposome and sprayable hydrogel into a dual-pronged strategy presents a patient-friendly method that simultaneously targets both the pro-metastatic PMN “soil" and metastatic tumor “seeds", resulting in significant inhibition of postoperative lung metastasis.

文獻引用產品：

作者單位：廣西醫科大學附屬腫瘤醫院

摘要：Ferroptosis is a newly identified type of regulated cell death characterized by iron-dependent lipid peroxidation. Among the main ferroptosis-suppressing systems, the dihydroorotate dehydrogenase (DHODH)- ubiquinone axis is closely related to mitochondria and energy metabolism, implying that the axis protects cells from oxidative stress damage via the maintenance of redox homeostasis. However, ferroptosis initiation requires a suitable oxidative environment and a breakthrough in redox homeostatic limitations by ferroptosis-suppressing systems. Hence, the nanoparticles are rationally engineered to achieve efficient ferroptosis induction by releasing dual-release free iron and disrupting ferroptosis-suppressing systems. Atovaquone (ATO)-loaded hollow mesoporous etching zeolitic imidazolate framework-67 double-coated iron oxide/calcium phosphate (Fe₃O₄/CaP) is conjugated with polyethylene glycol. The external double-coated Fe₃O₄/CaP structure enhances the efficiency of multiple reactive oxygen species (ROS) generation promoting oxidative stress. Still, it achieves free iron dual-release to increase the content of unstable iron pools for igniting the ROS storm and lipid peroxidation spark. The release of ATO not only affects the energy metabolism of the mitochondrial respiratory chain by binding to complex III but also downregulates DHODH to restrict the ubiquinol system to disrupt the ferroptosis-suppressing systems. Therefore, the design of this composite nanomedicine provides an approach for inducing ferroptosis and a theoretical basis for clinical ferroptosis anti-tumor trials.

Advanced Functional

Materials [IF=19]

摘要：Surface-enhanced Raman scattering (SERS) substrates based on 2D semimetallic materials have emerged as novel detecting platforms for detecting at the single-molecule level due to the high charge transfer efficiency between the layered materials and analytes. However, current methods such as chemical vapor deposition (CVD) or liquid-phase exfoliation face significant challenges in simultaneously achieving high yield and low defect density in preparing layered materials, which often leads to compromises in SERS efficiency or sensitivity, thereby limiting large-scale applications. Herein, an improved electrochemical cathodic exfoliation (ECE) protocol, developed through recent advancements, is employed to produce highly uniform and solution-processable TiSe₂, NbSe₂, and TaSe₂ monolayers with over 95% yield in 120 min. The SERS sensitivity (10^?16 M for Rhodamine 6G) of 2D materials from ECE rivals that of CVD-prepared monolayers due to their low defect density. Using NbSe₂ as the SERS substrate, matrix metalloproteinase-9 in tear fluid is detected across 0.01 to 100 ng mL^?1, outperforming conventional enzyme-linked immunosorbent assay methods that typically detect at 1 ng mL^?1. The scalability of the modified ECE process not only facilitates its integration into lateral flow immunoassays but also paves the way for bridging the gap between practical applications and highly sensitive SERS detection using 2D materials.